Amazon cGMP Mandate (2026)

Amazon requires dietary supplement sellers to demonstrate that their products are manufactured in facilities compliant with FDA's 21 CFR 111 or 117 cGMP regulations, verified by an accredited third-party testing, inspection, and certification (TIC) provider (policy effective April 2, 2024, with tiered coverage across all supplement categories). The approved-provider roster is short and updates inside Seller Central — confirm the current list there rather than relying on a fixed count. Response deadlines are listing-specific; sellers contacted by Amazon typically get about 30 days (program FAQ, accessed July 10, 2026). Amazon also offers a Fast-Track Compliance Program: brands already certified by an accepted Fast-Track partner (current partner list in Seller Central) may have compliance auto-validated using existing certification data. For 3PL evaluation, this mandate creates a new quality signal: a 3PL that can demonstrate its holding operations support or do not interfere with a brand's cGMP compliance becomes more valuable for Amazon sellers.