Amino Up Co., Ltd.
Amino Up Co., Ltd. is a Japanese functional ingredient company headquartered in Sapporo City, Hokkaido, Japan. The company developed AHCC (Active Hexose Correlated Compound) in collaboration with the University of Tokyo in 1989. AHCC is a standardized extract of cultured shiitake mushroom (Lentinula edodes) mycelia, produced through a proprietary long-term culturing process that yields unique partially acylated alpha-glucans. All AHCC bulk powder sold worldwide is manufactured exclusively at Amino Up's state-of-the-art facilities in Sapporo under strict quality controls. AHCC is supported by research from institutions in 20+ countries and is used in clinical settings, particularly in Japan.
Sapporo, Japan
Directory Listing · Records Reviewed
Public records and independent sources have been reviewed.
What this means →- MOQMOQ (Minimum Order Quantity)The smallest production run a manufacturer will accept for an order.
- Not publicly disclosed
- LEAD TIMELead TimeThe time from order placement to finished product delivery.
- Not publicly disclosed
§1Editorial assessment
Amino Up Co., Ltd. is a Japanese functional ingredient company headquartered in Sapporo City, Hokkaido, Japan. The company developed AHCC (Active Hexose Correlated Compound) in collaboration with the University of Tokyo in 1989. AHCC is a standardized extract of cultured shiitake mushroom (Lentinula edodes) mycelia, produced through a proprietary long-term culturing process that yields unique partially acylated alpha-glucans. All AHCC bulk powder sold worldwide is manufactured exclusively at Amino Up's state-of-the-art facilities in Sapporo under strict quality controls. AHCC is supported by research from institutions in 20+ countries and is used in clinical settings, particularly in Japan.
§2Our review
The six checks in our review, applied before any name appears in the directory. Each check is auto-derived from public evidence on this profile.
§3Inspection history
§4Certifications
Certification verification in progress. International supplier records require regional database lookups (EudraGMDP, Health Canada NHP, FSSC public register, JHFA directory). See our methodology.
§5Capability matrix
- PRODUCT TYPES
- AHCC (Active Hexose Correlated Compound) · Cultured Shiitake Mushroom Mycelia Extract · Oligonol (Lychee Polyphenol)
- CAPABILITIES
- Proprietary Mushroom Mycelia Culturing · Branded Ingredient Supply (AHCC) · Exclusive Worldwide Manufacturing (Sapporo Only) · Clinical Research Programs (University Collaborations) · ISO/GMP Quality Standards
§6Sources
Dietary supplement manufacturers must comply with 21 CFR Part 111 (Current Good Manufacturing Practice for dietary supplements). This includes requirements for personnel, facilities, equipment, production, laboratory operations, and record-keeping.
What We Couldn't Verify
- All manufacturing in Sapporo, Japan; on-site inspection was not conducted
- Single branded ingredient focus. AHCC is the primary commercial product
- US distribution through partner network (including Maypro), not direct sales office
- Certification details beyond cGMP not independently verified from public databases
Last reviewed: April 2, 2026
Disclosures
- No material connection exists between Inventory Ready and this company
For the check-by-check breakdown that produces this vendor's score, see our scoring framework. The connection map between Amino Up Co., Ltd. and other vendors, capabilities, and certifications is in the manufacturer atlas.
Our Evaluation Method
Every manufacturer assessment follows six principles:
- Evidence: Claims backed by documentation, not marketing copy
- Freshness: Information reviewed and dated within the last 12 months
- Provenance: Sources cited for every key claim
- Challenge: Inconsistencies flagged, not hidden
- Disclosure: Material connections stated directly on affected listings
- Abstention: When we can't assess, we say so explicitly
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