Gnosis by Lesaffre
Gnosis by Lesaffre is a biotechnology company specializing in fermentation-derived active ingredients, probiotics, and nutritional yeasts. Originally founded in 1989 as Gnosis S.p.A. in Desio, Italy (near Milan), the company was fully acquired by Lesaffre in 2018. Gnosis operates GMP manufacturing sites in Sant Antonino, Switzerland and Pisticci, Italy, with commercial offices in the US and China. The parent company Lesaffre is the world's largest yeast producer with EUR 2 billion in annual revenue. Key ingredients include vitaMK7 (naturally fermented vitamin K2 as MK-7), Quatrefolic (5-MTHF folate), and LifeinU L.rhamnosus GG probiotic. Gnosis has a joint venture with ADM (Red Star Yeast) in the United States.
Desio, Italy
Directory Listing · Records Reviewed
Public records and independent sources have been reviewed.
What this means →- MOQMOQ (Minimum Order Quantity)The smallest production run a manufacturer will accept for an order.
- Not publicly disclosed
- LEAD TIMELead TimeThe time from order placement to finished product delivery.
- Not publicly disclosed
§1Editorial assessment
Gnosis by Lesaffre is a biotechnology company specializing in fermentation-derived active ingredients, probiotics, and nutritional yeasts. Originally founded in 1989 as Gnosis S.p.A. in Desio, Italy (near Milan), the company was fully acquired by Lesaffre in 2018. Gnosis operates GMP manufacturing sites in Sant Antonino, Switzerland and Pisticci, Italy, with commercial offices in the US and China. The parent company Lesaffre is the world's largest yeast producer with EUR 2 billion in annual revenue. Key ingredients include vitaMK7 (naturally fermented vitamin K2 as MK-7), Quatrefolic (5-MTHF folate), and LifeinU L.rhamnosus GG probiotic. Gnosis has a joint venture with ADM (Red Star Yeast) in the United States.
§2Our review
The six checks in our review, applied before any name appears in the directory. Each check is auto-derived from public evidence on this profile.
§3Inspection history
§4Certifications
Certification verification in progress. International supplier records require regional database lookups (EudraGMDP, Health Canada NHP, FSSC public register, JHFA directory). See our methodology.
§5Capability matrix
- PRODUCT TYPES
- Fermentation-Derived Active Ingredients · vitaMK7 (Vitamin K2 as MK-7) · Quatrefolic (5-MTHF Folate) · Probiotics (LifeinU L.rhamnosus GG) · Nutritional Yeasts · S-Adenosyl-L-Methionine (SAMe)
- CAPABILITIES
- Fermentation-Based Manufacturing · GMP Manufacturing (Switzerland & Italy) · Branded Ingredient Development · Clinical Research Programs · US Commercial Office · Red Star Yeast JV with ADM (US)
§6Sources
Dietary supplement manufacturers must comply with 21 CFR Part 111 (Current Good Manufacturing Practice for dietary supplements). This includes requirements for personnel, facilities, equipment, production, laboratory operations, and record-keeping.
What We Couldn't Verify
- R&D and offices in Desio, Italy; manufacturing in Switzerland and Italy; on-site inspection was not conducted
- Acquired by Lesaffre (French parent) in 2018. Corporate structure is complex
- GMP manufacturing sites claimed but not independently verified from public directories
- US commercial office exists but specific location not confirmed
Last reviewed: April 2, 2026
Disclosures
- No material connection exists between Inventory Ready and this company
For the check-by-check breakdown that produces this vendor's score, see our scoring framework. The connection map between Gnosis by Lesaffre and other vendors, capabilities, and certifications is in the manufacturer atlas.
Our Evaluation Method
Every manufacturer assessment follows six principles:
- Evidence: Claims backed by documentation, not marketing copy
- Freshness: Information reviewed and dated within the last 12 months
- Provenance: Sources cited for every key claim
- Challenge: Inconsistencies flagged, not hidden
- Disclosure: Material connections stated directly on affected listings
- Abstention: When we can't assess, we say so explicitly
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