Amazon Supplement Requirements: What Brands Need to Know in 2026

Top 7 Amazon Supplement Compliance Requirements (2026 Checklist)

Amazon's supplement rules draw on FDA regulations (21 CFR Part 101 and Part 111 or Part 117), Amazon's own policies, and California's Proposition 65 warning rules. The seven checkpoints below follow Amazon's dietary supplements policy. Each item links to Amazon's policy page and, where one applies, the underlying regulation, so you can verify against the source.

1. 1

   Third-Party cGMP Facility Verification

   Amazon's dietary supplements policy requires every supplement to be made in a facility that complies with FDA's cGMP rules (21 CFR Part 111 or Part 117, or an equivalent), shown by a cGMP audit or certification from an accredited third party. An FDA inspection does not count, and neither does a first-party, private, or consulting audit; the certificate must be in good standing and not expired. If the facility holds a current GFSI (Global Food Safety Initiative) food safety certification, Amazon says this may satisfy the cGMP requirement.

   Primary sources: Amazon Seller Central: Dietary supplements policy; 21 CFR Part 111 (FDA cGMP regulation).

   Read more: What Amazon Now Requires.

2. 2

   Authorized TIC Provider (Current List in Seller Central)

   Your documents reach Amazon through a testing, inspection, and certification (TIC) provider that Amazon has authorized; you no longer submit them directly. You can use another accredited lab, but an authorized TIC provider must then validate its results. Amazon says its list is updated monthly, and the Select a Provider menu in Seller Central has the current list.

   Primary sources: Amazon Seller Central: TIC services and authorized providers.

   Read more: Amazon's Authorized TIC Providers.

3. 3

   Compliance Fast-Track Program (Skip Document Submission)

   If your product is certified by an organization taking part in Amazon's Compliance Fast-Track program, that organization shares the compliance information with Amazon, and Amazon says it will automatically validate the product's compliance status, so you do not submit compliance documents yourself. Amazon lists the participating organizations, including those for dietary supplements, on its Fast-Track page.

   Primary sources: Amazon Seller Central: Compliance Fast-Track program.

   Read more: Compliance Fast-Track Program.

4. 4

   Category-Specific Testing (NSF/ANSI 173-2024)

   Supplements intended for bodybuilding, joint health, sexual enhancement, sports nutrition, or weight management follow NSF/ANSI 173-2024 (the American National Standard for dietary supplements) or an equivalent. Amazon's policy requires them to be tested for heavy metal and microbial contaminants, for dietary ingredient amounts within FDA's label tolerances, and for known adulterants.

   Primary sources: Amazon Seller Central: Dietary supplements policy (Testing); NSF International (NSF/ANSI 173-2024 standard documentation).

   Read more: Category-Specific Requirements.

5. 5

   Supplement Facts Panel Alignment

   Amazon's policy bars listing text and images from stating extract or ingredient weights that do not match the amounts on the Supplement Facts Panel. "1000mg" in the title with "500mg" on the panel is a violation. NutraIngredients reported in March 2026 that Amazon would check this with AI systems that scan titles, descriptions, and images.

   Primary sources: 21 CFR 101.36 (Supplement Facts label format); Amazon Seller Central: Dietary supplements policy (Claims).

   Read more: Claims Compliance section.

6. 6

   Deactivation Triggers and Prop 65 Warnings

   Amazon deactivates a listing right away when the product fails testing or its documents fail review, and it can remove listings that break its claims rules, such as disease claims or mismatched ingredient weights. Separately, California's Proposition 65 can require a warning: Amazon asks you to decide for every listing whether the product needs one and, if it does, to select the warning type in the listing's Compliance tab.

   Primary sources: Amazon Seller Central: Dietary supplements policy; Amazon Seller Central: California Proposition 65.

   Read more: Common Reasons for Listing Deactivation.

7. 7

   Ongoing Compliance Maintenance

   Compliance is not a one-time gate. Keep the facility's cGMP certificate current, since Amazon does not accept an expired one; keep listing claims matched to the label; and watch Account Health, where Amazon sends document requests. Amazon can select products for periodic testing or inspection at any time.

   Primary sources: Amazon Seller Central: TIC services (Account Health); 21 CFR Part 111.

   Read more: Maintaining Ongoing Compliance.

What Amazon Now Requires

Amazon's supplement requirements have three layers. The first is cGMP facility verification. The second is product-level documentation. The third is claims compliance.

1. cGMP Facility Verification (Expanded December 2025)

Amazon's dietary supplements policy requires every supplement sold on Amazon to be made in a facility that complies with FDA's cGMP rules, shown by a cGMP audit or certification from an accredited third party. This is not the same as FDA facility registration. A cGMP audit means an accredited third party has checked the manufacturing facility against 21 CFR Part 111; Amazon also accepts 21 CFR Part 117 or an equivalent. If the facility holds a current GFSI (Global Food Safety Initiative) food safety certification, Amazon says this may satisfy the cGMP requirement. For a full explanation of Part 111, see our Part 111 compliance guide.

NutraIngredients reported in December 2025 that Amazon was rolling out this cGMP requirement to all dietary supplement sellers in phases, contacting covered companies. Supplements for bodybuilding, joint health, sexual enhancement, sports nutrition, and weight management also need product testing (see Category-Specific Requirements below). Amazon notifies you in Account Health and gives each listing an "Address issue by" date, so start as soon as the notice arrives.

2. Product Documentation

Amazon can select products for testing or inspection at any time and reserves the right to ask for more information. Documents now go to an Amazon-authorized TIC provider, which submits them to Amazon for you. Be prepared to provide:

• ✓A current cGMP certificate from an accredited third party for the manufacturing facility, or the facility's current GFSI food safety certificate
• ✓Test results for contaminants, ingredient amounts, and known adulterants, if your product is in one of the five categories with extra testing
• ✓Product images that show the full label in English, including the Supplement Facts panel, and all sides of the product or its packaging

3. Claims Compliance

Amazon's policy bars listing text and images from stating extract or ingredient weights that do not match the amounts on your Supplement Facts Panel. If your listing says "1000mg Vitamin C" but your label says "500mg," that's a violation. Inflating an extract into a raw-herb weight, or giving a weight without the ingredient name or the portion size, is also barred. Amazon allows the same amount in a mathematically equivalent unit when it matches the panel.

NutraIngredients reported in March 2026 that Amazon was rolling out an updated policy on March 31 requiring listing content to match the Supplement Facts Panel, with enforcement largely powered by AI systems that scan titles, descriptions, and images. Listings with conflicting information may be flagged or removed, the report said.

Amazon's policy also bars disease claims (claims to diagnose, cure, reduce, treat, or prevent a disease) unless the statement has FDA approval, and it bars disease names in keywords. Structure/function claims are a different category. For a full guide, see our structure/function claims guide.

Amazon's Authorized TIC Providers

Amazon routes supplement documents through testing, inspection, and certification (TIC) service providers it has authorized. You can use another accredited lab for testing, but an authorized TIC provider must then validate its results. Amazon says its list is updated monthly; the Select a Provider menu in Seller Central has the current list. On October 4, 2026, Amazon's help page listed these eight providers for US dietary supplements:

• Certified Laboratories
• Cotecna
• Eurofins
• ITS - Intertek
• Mérieux NutriSciences
• NSF
• SGS
• UL - Underwriters Laboratories

Ask your manufacturer for a copy of its current cGMP certificate, or its GFSI food safety certificate, and check that an accredited third party issued it. If it has neither, it will need an audit before your listing can pass review. Audit timelines depend on the auditor and on the manufacturer's readiness.

For guidance on evaluating certifications more broadly, see our choosing certifications guide. If you are still selecting a manufacturer, our source-checked US supplement manufacturers guide documents verification status per company.

Compliance Fast-Track Program

Amazon's Compliance Fast-Track program covers dietary supplements. If your product is certified by a participating organization, that organization shares your compliance information with Amazon, and Amazon says it will automatically validate the product's compliance status, so you do not submit compliance documents yourself. Amazon lists the participating organizations and the product categories each covers on its Fast-Track page, and the list can change, so check it before choosing a certifier. Amazon says a mismatch between the certifier's records and your listing (for example the ASIN or brand name) is the most common reason a certified product stays suppressed.

Category-Specific Requirements

Amazon's dietary supplements policy adds product testing for supplements intended for bodybuilding, joint health, sexual enhancement, sports nutrition, or weight management. These products follow NSF/ANSI 173-2024 (the American National Standard for dietary supplements) or an equivalent, and must be tested for heavy metal and microbial contaminants, for dietary ingredient amounts within the tolerances in 21 CFR 101.36 and 101.9(g), and for known adulterants listed in NSF/ANSI 173-2024. Depending on the finished product's components, Amazon says products may also be tested for pesticides. The testing goes through an Amazon-authorized TIC provider.

If your product falls in one of these five categories, plan this testing before launch and ask your manufacturer which of these tests its certificates of analysis already cover.

Why Amazon Deactivates Supplement Listings

A deactivated listing stays inactive until you fix the issue, for example by sending compliant documents. Amazon's dietary supplements policy names these triggers.

• Missing or expired cGMP certificate. No current cGMP audit or certification from an accredited third party submitted through your TIC provider by the listing's due date. An FDA inspection does not count, and neither does a first-party, private, or consulting audit or an expired certificate.
• Ingredient amounts that don't match the Supplement Facts Panel. Listing text or images that state extract or ingredient weights different from the amounts on the panel.
• Disease claims in listing content. Any claim to diagnose, cure, reduce, treat, or prevent a disease, unless the statement has FDA approval. Amazon's policy also bars disease names in keywords.
• Failed testing or document review. Amazon can select products for testing or inspection at any time. A product that fails testing, or whose documents fail review, is deactivated right away and stays deactivated until you send compliant documents.
• Prohibited products. Amazon bars some supplements outright, including those named in an FDA recall or safety alert and those containing controlled substances or prescription-only ingredients.

Maintaining Ongoing Compliance

Amazon compliance is not a one-time activity. Requirements evolve, and your documentation must stay current.

Compliance Checklist

• ✓Confirm your manufacturer holds a current cGMP audit or certification from an accredited third party, or a current GFSI food safety certification, which Amazon says may satisfy the cGMP requirement. Obtain a copy of the certificate and note the expiration date.
• ✓Keep current certificates of analysis for every product and batch. When Amazon notifies you in Account Health, submit a test request form to an authorized TIC provider before the listing's "Address issue by" date; Amazon says listings are not deactivated while that request is in progress.
• ✓Audit your listing content quarterly. Compare every claim against your Supplement Facts Panel. Remove or correct any mismatches.
• ✓Decide for every listing whether the product needs a California Prop 65 warning. If it does, select the warning type, and the chemical name if needed, in the listing's Compliance tab; Amazon asks you not to send warnings any other way, such as by email.
• ✓If you reformulate a product, update your listing to match. The COA, label images, and claims must reflect the current formulation.
• ✓Track your cGMP certificate's expiration date. Amazon does not accept an expired certificate.
• ✓Watch Account Health and your email. Amazon sends document requests as email notifications in Account Health.

For understanding COA documentation in depth, see our guide to reading a COA. For testing protocols your manufacturer should follow, see our supplement testing requirements guide.